Synthesis, characterization, and investigations of antimicrobial activity of benzopyrans, benzofurans and spiro[4.5]decanes
SYNTHETIC COMMUNICATIONS, cilt.48, sa.19, ss.2510-2521, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 19
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/00397911.2018.1509094
- Dergi Adı: SYNTHETIC COMMUNICATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2510-2521
- Anahtar Kelimeler: Benzopyran, benzofuran, spiro[4.5]decane, cyclization, manganese(III) acetate, CERIUM(IV) AMMONIUM-NITRATE, ELECTRON-RICH ALKENES, MANGANESE(III) ACETATE, CLAISEN REARRANGEMENT, RADICAL CYCLIZATION, BIOLOGICAL-ACTIVITY, RING EXPANSION, DIHYDROPYRANS, DERIVATIVES, 3-OXOPROPANENITRILES
- Gazi Üniversitesi Adresli: Evet
Özet
In this study, the radical cyclization reactions of cyclic 1,3-dicarbonyl compounds (1a-c) and a, b-unsaturated alcohols (2a-d) through Mn(OAc) 3 were performed. A series of biologically interesting dihydropyrans (3-5) and dihydrofurans (6-18) were synthesized as a result of these reactions. Spiro compounds (19-20) were obtained from the reactions of 1,3-dicarbonyl compounds and (E)-2,4-diphenyl-but-3-en2-ol (2e). The unique structure of compound 19 was also confirmed by X-ray crystallography. In addition, the antibacterial activities of synthesized compounds were screened against some bacteria. Their zone diameters showed better results than some known antibiotics.