Immunohistochemical and Ultrastructural Changes Related To Methylphenidate In Rat Pituitary and Pineal Glands


Elmas Ç. , Bahçelioğlu M. , Erdogan D., Gozil R., Take Kaplanoğlu G. , Calguner E., ...Daha Fazla

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.29, ss.476-493, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Sayfa Sayıları: ss.476-493

Özet

Objective: The presence of a dopaminergic function in pituitary and pineal glands is well known. Methylphenidate (MPH), a widely prescribed psychostimulant for attention deficit/hyperactivity disorder, is an indirect dopamine agonist which could have the capacity of influencing the hypothalamo-neurohypophysial system with the pineal gland. Our aim is to investigate dose-dependent immunohistochemical dopamine 2 expression, possible cell apoptosis and ultrastructural changes of the rat pituitary and pineal gland tissue, to demonstrate possible toxicity of the chronic extended use of the MPH.