Immunohistochemical and Ultrastructural Changes Related To Methylphenidate In Rat Pituitary and Pineal Glands
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.29, ss.476-493, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29
- Basım Tarihi: 2012
- Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.476-493
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Objective: The presence of a dopaminergic function in pituitary and pineal glands is well known. Methylphenidate (MPH), a widely prescribed psychostimulant for attention deficit/hyperactivity disorder, is an indirect dopamine agonist which could have the capacity of influencing the hypothalamo-neurohypophysial system with the pineal gland. Our aim is to investigate dose-dependent immunohistochemical dopamine 2 expression, possible cell apoptosis and ultrastructural changes of the rat pituitary and pineal gland tissue, to demonstrate possible toxicity of the chronic extended use of the MPH.