Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits

AKAR F., Pektas M. B., Tufan C., Soylemez S., SEPİCİ DİNÇEL A., Ulus A. T., ...Daha Fazla

CARDIOVASCULAR DRUGS AND THERAPY, cilt.25, sa.2, ss.119-131, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10557-010-6255-7
  • Dergi Adı: CARDIOVASCULAR DRUGS AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-131
  • Anahtar Kelimeler: Resveratrol, Endothelial and vascular function, Superoxide, Nitric oxide, Insulin, Alloxan, Diabetic rabbits, ENDOTHELIAL DYSFUNCTION, TRANS-RESVERATROL, NITRIC-OXIDE, FEMALE RATS, CELLS, SUPEROXIDE, RELAXATION, AORTA, SIRT1, ANTIOXIDANT
  • Gazi Üniversitesi Adresli: Evet

Özet

Resveratrol has been shown to have vasoprotective effects by upregulating oxidative defense mechanisms in a variety of pathophysiological conditions. However, the effect of resveratrol on diabetic oxidative stress and vascular and metabolic abnormalities is not completely understood. Therefore, this study was designed to evaluate whether long-term resveratrol supplementation has a protective effect on vascular function and integrity in association with metabolic parameters and oxidative stress in insulin-dependent diabetes.