The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts


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Turan N., Csonka C., Csont T., Giricz Z., Fodor G., Bencsik P., ...Daha Fazla

CARDIOVASCULAR RESEARCH, cilt.70, sa.2, ss.384-390, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.cardiores.2005.12.012
  • Dergi Adı: CARDIOVASCULAR RESEARCH
  • Sayfa Sayıları: ss.384-390

Özet

Objectives: 3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, has been shown to protect against ischemic injury in the brain and in the heart via a preconditioning-like effect; however, the cellular mechanism is not known. The aim of the present study was to investigate if 3-NP pretreatment reduces infarct size and if altered metabolism of nitric oxide and reactive oxygen species are involved.