The investigation of the potential antidepressant-like activity of Xanthium orientale subsp. italicum (Moretti) Greuter in rodents

GÜRAĞAÇ DERELİ F. T., İlhan M., Sobarzo-Sanchez E., AKKOL E.

JOURNAL OF ETHNOPHARMACOLOGY, vol.258, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 258
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jep.2020.112914
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Bibliography of Social Sciences, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, CINAHL, EMBASE, Index Islamicus, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Antidepressant, Asteraceae, Monoamine oxidase, Sesquiterpene lactone, Xanthium orientale, Xanthatin, Xanthinosin, CELL-CYCLE ARREST, SESQUITERPENE LACTONES, MEDICINAL-PLANTS, HEDYOSMUM-BRASILIENSE, STRUMARIUM L., XANTHATIN, XANTHANOLIDES, CONSTITUENTS, APOPTOSIS, ROOTS
  • Gazi University Affiliated: Yes


Ethnopharmacological relevance: Ethnobotanical surveys revealed that Xanthium orientale subsp. italicum (Moretti) Greuter has been used against central nervous system disorders in Turkish folk medicine. The aim of the present study is to verify the folkloric assertion on this plant. The compounds responsible for the activity were investigated using bioassay-guided fractionation procedures.