MEDICINAL CHEMISTRY RESEARCH, vol.22, no.10, pp.4893-4908, 2013 (SCI-Expanded)
Article / Article
MEDICINAL CHEMISTRY RESEARCH
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Synthesis, Anticancer activity, 1H-Pyrazoles, Pyridine, MTT, PRELIMINARY BIOLOGICAL EVALUATION, RAPID COLORIMETRIC ASSAY, HYDRAZONE DERIVATIVES, PYRAZOLE DERIVATIVES, POTENTIAL AGENTS, APOPTOSIS, DISCOVERY, DESIGN, GROWTH, CELLS
Gazi University Affiliated:
A novel combinatorial library of ester and amide derivatives of 1,3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of these, compounds 4c and 5f were found as the most promising anticancer agents with IC50 values of 8.12 and 9.63 mu M in Raji cells, respectively. All compounds exhibited suitable drug-like characteristics according to Lipinski's rule.