Synthesis, cytotoxicity, and molecular properties prediction of novel 1,3-diarylpyrazole derivatives

BAYTAŞ S. , Inceler N., Yilmaz A.

MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.10, ss.4893-4908, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 22 Konu: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00044-013-0505-8
  • Sayfa Sayıları: ss.4893-4908


A novel combinatorial library of ester and amide derivatives of 1,3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of these, compounds 4c and 5f were found as the most promising anticancer agents with IC50 values of 8.12 and 9.63 mu M in Raji cells, respectively. All compounds exhibited suitable drug-like characteristics according to Lipinski's rule.