Incidental detection of medullary thyroid carcinoma on Ga-68 PSMA PET/MRI in a patient with prostate cancer Détection fortuite d’un carcinome médullaire de la thyroïde au Ga-68 PSMA PET/IRM chez un patient atteint d’un cancer de la prostate

GÜLBAHAR ATEŞ S., AYDOS U., ATAY L. Ö.

Medecine Nucleaire, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.mednuc.2026.01.191
  • Dergi Adı: Medecine Nucleaire
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: Ga-68 prostate-specific membrane antigen PET, Medullary thyroid cancer, PET/MRI, Prostate cancer
  • Gazi Üniversitesi Adresli: Evet

Özet

A 73-year-old male patient with prostate cancer underwent a staging Gallium-68 (Ga-68) prostate-specific membrane antigen (PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI). Ga-68 PSMA PET/MRI revealed cervical and mediastinal lymph nodes, and a thyroid mass with moderately increased uptake, as well as extensive metastases of prostate cancer. The thyroid mass and lymph nodes were assessed suspicious for a second primary thyroid cancer due to their relatively lower radiotracer uptake. Pathological examination demonstrated multifocal medullary thyroid carcinoma (MTC) with multiple lymph node metastases. Our case highlights incidental detection of MTC on Ga-68 PSMA PET, likely related to PSMA expression in tumor-associated neovasculature. PSMA-targeted imaging and radioligand therapy could provide new diagnostic and therapeutic opportunities in patients with MTC.