Preparation and Characterization of pH-Responsive Kaolin-Containing Pectin/Poly(Acrylic Acid) IPN Hydrogel for Potential Colon-Targeted Drug Delivery
Journal of Applied Polymer Science, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/app.71221
- Dergi Adı: Journal of Applied Polymer Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: acrylic acid, colon-targeted, diclofenac sodium, IPN hydrogel, kaolin, pectin
- Gazi Üniversitesi Adresli: Evet
Özet
Diclofenac sodium (DS) is a widely used non-steroidal anti-inflammatory drug with a short biological half-life, necessitating frequent dosing. In this study, a pH-responsive kaolin-containing pectin/poly(acrylic acid) interpenetrating polymer network (IPN) hydrogel was developed for controlled, colon-targeted delivery of DS. The hydrogels were characterized by attenuated total reflectance–Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Swelling behavior, gel content, and degradation were also evaluated. ATR-FTIR analysis confirmed the presence of the characteristic functional groups associated with the hydrogel constituents. SEM observations demonstrated enhanced porosity in kaolin-containing hydrogel and XRD analysis revealed that the hydrogel network was amorphous. Kaolin incorporation contributed to a more stable network structure and improved gel content while maintaining pH-responsive swelling. In vitro release studies showed minimal DS release at pH 1.2, followed by enhanced release at pH 7.4, with kaolin-containing hydrogels exhibiting a more gradual and sustained profile. At pH 7.4, the kaolin-containing pectin/poly(acrylic acid) IPN hydrogel achieved nearly 97% cumulative release at 25 h. Kinetic analysis at pH 7.4 showed good agreement with the zero-order, Higuchi, and Korsmeyer–Peppas models. Overall, the developed pH-sensitive IPN hydrogels show strong potential for prolonged and site-specific drug delivery to the colon.