How potential endocrine disruptor deltamethrin effects antioxidant enzyme levels and total antioxidant status on model organisms Potansiyel Endokrin Bozucu Deltametrin, Model Organizmalarda Antioksidan Enzim Düzeylerini ve Toplam Antioksidan Durumu Nasıl Etkiler

Isildar G. Y., GÜNAL A. Ç., Sahin D., Memmi B. K., SEPİCİ DİNÇEL A.

Turkish Journal of Biochemistry, cilt.45, sa.4, ss.415-421, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2019-0382
  • Dergi Adı: Turkish Journal of Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.415-421
  • Anahtar Kelimeler: antioxidant enzymes, invertebrate model organism, synthetic pyrethroid, total antioxidant status, total haemocyte counts, ASTACUS-LEPTODACTYLUS ESCHSCHOLTZ, TOTAL HEMOCYTE COUNTS, FRESH-WATER FISH, OXIDATIVE STRESS, CYPRINUS-CARPIO, ACUTE TOXICITY, CRAYFISH, EXPOSURE, BIOMARKERS, PARAMETERS
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2020 De Gruyter. All rights reserved.Objective: Deltamethrin, synthetic pyrethroid, is a suspected endocrine disruptor contaminating ecosystems as toxic pollutant via agricultural activities and vector controls. The objective of the study is to determine the possible effects on human by evaluating antioxidant enzyme levels and total antioxidant status (TAS) of invertebrate model organism crayfish exposure to sublethal deltamethrin. Materials and methods: Crayfish were exposed to 0.05 μg/L deltamethrin for 48 h and 7 days. Hemolymph samples were taken for TAS and total haemocyte counts (THCs). Gill, hepatopancreas and muscle tissues were examined for superoxide dismutase (SOD), glutathion peroxidase (GPx) and catalase (CAT) enzyme activities. Results: THCs were decreased (p < 0.05) and hemolymph TAS levels were increased according to control groups. Gill SOD, CAT and GPx enzyme activities were significantly rised. Hepatopancreas SOD activities unchanged. Hepatopancreas CAT activities were increased significantly after 48 h (p < 0.05), but returned back to controls after 7 days. Hepatopancreas GPx and muscle SOD activities were rised (p < 0.05), while muscle CAT and GPx values did not affect from deltametrin. Conclusion: Deterioration of ecosystems are directly affect the humans. The toxic effects of deltamethrin for different stages of organisms on the food web will provide basic data to understand and estimate the effects on the human beings.