The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis

Yayla C., Acikgoz S. K. , Yayla K. G. , Acikgoz E., CANPOLAT U., Kirbas O., ...More

BIOMARKERS IN MEDICINE, vol.10, no.4, pp.367-373, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.2217/bmm-2015-0016
  • Title of Journal : BIOMARKERS IN MEDICINE
  • Page Numbers: pp.367-373


Aim: Platelet-to-lymphocyte ratio (PLR) was proposed as a novel indirect marker of inflammation. We aimed to evaluate the relationship between PLR and aortic stenosis (AS). Patients & methods: The study population included 453 patients of which 98 patients with severe AS, 206 patients with mild-to-moderate AS and 149 patients as control. Results: PLR was significantly increased in parallel to the severity of AS (p < 0.001). There was significant positive correlation between PLR and maximum, and mean systolic transaortic gradient (all p < 0.001). Also, PLR was correlated with C-reactive protein and neutrophil-to-lymphocyte ratio (all p < 0.001) and PLR was independently associated with the presence of AS (p < 0.001). Conclusion: We found a significant relationship between PLR and AS.