Promising Perspective to Facioscapulohumeral Muscular Dystrophy Treatment: Nutraceuticals and Phytochemicals.

HANGÜL C., Karaüzüm S. B., Akkol E., Demir-Dora D., Çetin Z., Saygılı E. İ., ...Daha Fazla

Current neuropharmacology, cilt.19, sa.12, ss.2276-2295, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1570159x19666210726151924
  • Dergi Adı: Current neuropharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.2276-2295
  • Anahtar Kelimeler: Facioscapulohumeral muscular dystrophy, FSHD, natural compound, phytochemical, nutraceutical, skeletal muscle, dystrophy, NF-KAPPA-B, OXIDATIVE STRESS, HISTONE ACETYLTRANSFERASE, DOUBLE-BLIND, GENE-EXPRESSION, D4Z4 REPEAT, MENTAL-RETARDATION, DNA METHYLATION, DUX4 EXPRESSION, CANDIDATE GENE
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2021 Bentham Science Publishers.Facioscapulohumeral Muscular Dystrophy (FSHD) is in the top three list of all dystrophies with an approximate 1:8000 incidence. It is not a life-threatening disease; however, the progression of the disease extends over being wheelchair bound. Despite some drug trials continuing, including DUX4 inhibition, TGF-ß inhibition and resokine which promote healthier muscle, there is not an applicable treatment option for FSHD today. Still, there is a need for new agents to heal, stop or at least slow down muscle wasting. Current FSHD studies involving nutraceuticals as vitamin C, vitamin E, coenzyme Q10, zinc, selenium, and phytochemicals as curcumin or genistein, daidzein flavonoids provide promising treatment strategies. In this review, we present the clinical and molecular nature of FSHD and focus on nutraceuticals and phytochemicals that may alleviate FSHD. In the light of the association of impaired pathophysiological FSHD pathways with nutraceuticals and phytochemicals according to the literature, we present both studied and novel approaches that can contribute to FSHD treatment.