Effects of chitosan and platelet-rich plasma on facial nerve regeneration in an animal model
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.279, sa.2, ss.987-994, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 279 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s00405-021-06859-6
- Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.987-994
- Anahtar Kelimeler: Chitosan, Platelet-rich plasma, Facial nerve, Regeneration, Rat model, MESENCHYMAL STEM-CELLS, GROWTH-FACTOR PDGF, QUALITY-OF-LIFE, SCIATIC-NERVE, METHYLPREDNISOLONE, PARALYSIS, INJURY, EXPRESSION, SYSTEM, REPAIR
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Purpose There is still no widely-accepted local agent proven to be effective in nerve regeneration. We aimed to investigate the effects of chitosan gel and platelet-rich plasma Materials and methods Electrophysiological measurements were performed before and immediately after injury. The injured nerves were covered with spongostan impregnated with the following agents: Group 1 (Control Group): Saline at a dose of 50 mu l; Group 2: Chitosan (CHT) at a dose of 50 mu l; Group 3: PRP at a dose of 50 ml; and Group 4: a solution of CHT with PRP (1:1). The final measurements were performed after 3 weeks and the injured nerve of each rat was removed. Results There were statistically-significant differences between the groups regarding the measurements of the after-treatment values of stimulus threshold (p < 0.05). The best improvement in electrophysiological measurement and histopathological evaluation was found in Group 4 (CHT-PRP). Conclusion Chitosan gel has a positive effect on nerve healing and applying it along with PRP can enhance the effect of chitosan.