Cytokine associated neopterin response of peripheral blood mononuclear cells to in vitro Epstein-Barr virus transformation process of B lymphocytes

Aral L. A., Yucel A.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.43, sa.4, ss.562-568, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3906/sag-1203-6
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.562-568
  • Anahtar Kelimeler: B lymphocyte transformation, EBV, in vitro, neopterin, CORD BLOOD
  • Gazi Üniversitesi Adresli: Evet

Özet

Aim: The Epstein-Barr Virus (EBV) is a human herpes virus that infects B lymphocytes latently and immortalises the cells due to transformation. EBV infection is asymptomatic in childhood, while it may cause a self-limiting lymphoproliferative disorder in adolescence. This study aimed to show the association between in vitro transformation of B lymphocytes via EBV and the levels of neopterin with different accompanying cytokine responses.