Cytokine associated neopterin response of peripheral blood mononuclear cells to in vitro Epstein-Barr virus transformation process of B lymphocytes


Aral L. A., Yucel A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.43, no.4, pp.562-568, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3906/sag-1203-6
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.562-568
  • Keywords: B lymphocyte transformation, EBV, in vitro, neopterin, CORD BLOOD
  • Gazi University Affiliated: Yes

Abstract

Aim: The Epstein-Barr Virus (EBV) is a human herpes virus that infects B lymphocytes latently and immortalises the cells due to transformation. EBV infection is asymptomatic in childhood, while it may cause a self-limiting lymphoproliferative disorder in adolescence. This study aimed to show the association between in vitro transformation of B lymphocytes via EBV and the levels of neopterin with different accompanying cytokine responses.