Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

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Ahmed S., Khan H., Aschner M., Mirzae H., AKKOL E., Capasso R.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.21, sa.16, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 21 Sayı: 16
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/ijms21165622
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: furanocoumarin, apoptosis, autophagy, metastasis, cell cycle arrest, NF-KAPPA-B, MEDIATED MULTIDRUG-RESISTANCE, CELL-CYCLE ARREST, IN-VITRO, ANGELICA-DAHURICA, CANCER-CELLS, MATRIX METALLOPROTEINASES, DIETARY FUROCOUMARINS, SIGNALING PATHWAY, PSORALEN REVERSES
  • Gazi Üniversitesi Adresli: Evet

Özet

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins' defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.