High-Risk ALK Negative Anaplastic Large-Cell Lymphoma Presenting with Hypereosinophilic Syndrome in a 2.5-Year-Old Child


Tekkesin F., PINARLI F. G. , KAYA Z. , Oguz A., KARADENİZ C. , OKUR A. , ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.29, sa.8, ss.686-690, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Konu: 8
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/08880018.2012.725238
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Sayfa Sayıları: ss.686-690

Özet

The hypereosinophilic syndromes (HES) are characterized by prolonged nonreactive peripheral blood hypereosinophilia with tissue damage. The lymphocytic HES variant can precede malignant clonal T-cell disease in adults but it is extremely rare to be the presenting feature of lymphomas in children. Here we present a 2.5-year-old boy with HES and mediastinal T-cell anaplastic lymphoma kinase (ALK) negative systemic anaplastic large-cell lymphoma. Mature and immature eosinophils without blasts were shown on bone marrow aspiration while biopsy revealed malignant infiltration. The patient responded well to initial corticosteroid therapy, but high-risk features make a challenge of finding the cure in this extremely rare case.