HLA-DRB1 alleles and Henoch-Schonlein purpura: Susceptibility and severity of disease

Soylemezoglu O., Peru H., GÖNEN S., Cetinyurek A., BUYAN N.

JOURNAL OF RHEUMATOLOGY, cilt.35, sa.6, ss.1165-1168, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 2008
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1165-1168
  • Anahtar Kelimeler: Henoch-Schonlein purpura, human leukocyte antigen, susceptibility, GIANT-CELL ARTERITIS, POLYMYALGIA-RHEUMATICA, IGA NEPHROPATHY, HLA, ASSOCIATION, NEPHRITIS, LOCUS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective. The genetic basis of susceptibility to Henoch-Schonlein purpura (HSP) may be conferred by a number of gene loci, including the MHC. Associations between human leukocyte antigen (HLA) and disease can help to establish a basis for susceptibility and assist in the prediction of the outcome and clinical heterogeneity. We aimed to investigate the implications of the HLA-DRB1 locus and the susceptibility to HSP, and to determine if there are associations with joint, gastrointestinal, and renal manifestations of the disease.