EXPRESSION OF iNOS, COX-2 AND VEGF IN CANINE MAMMARY TUMOURS AND NON-NEOPLASTIC MAMMARY GLANDS: ASSOCIATION WITH CLINICOPATHOLOGICAL FEATURES AND TUMOUR GRADE


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Anadol E., Yar Sağlam A. S. , Gültiken N., Karakaş K., Alcigir E., Alkan H., ...More

ACTA VETERINARIA HUNGARICA, vol.65, pp.382-393, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2017
  • Doi Number: 10.1556/004.2017.036
  • Journal Name: ACTA VETERINARIA HUNGARICA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.382-393
  • Keywords: Canine mammary tumour, gene expression, iNOS, COX-2, VEGF, OXIDE SYNTHASE EXPRESSION, HUMAN BREAST-CANCER, NITRIC-OXIDE, CYCLOOXYGENASE-2 EXPRESSION, PROGNOSTIC-SIGNIFICANCE, GROWTH-FACTOR, CARCINOMA, ANGIOGENESIS, DOGS, SURVIVAL

Abstract

The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.