CLINICAL-EXPERIENCE WITH SULBACTAM CEFOPERAZONE IN CRITICAL SURGICAL INFECTIONS


ENGIN A., MENTES B., TURET S.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.49, sa.6, ss.989-997, 1991 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Konu: 6
  • Basım Tarihi: 1991
  • Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Sayfa Sayıları: ss.989-997

Özet

The clinical efficacy and safety of sulbactam plus cefoperazone (SBT/CPZ) was evaluated. Twenty-three selected patients with debilitating serious infections following major surgical interventions were treated with SBT/CPZ in a ratio of 1:1 (weight/weight) by intravenous infusion for seven to 15 days (average, 8.9 days). Twenty patients (87%) were infected with beta-lactamase-producing bacteria, 48% of which were resistant to multiple cephalosporins. The overall clinical efficacy rate reached 91%. Both clinical cure and bacteriological eradication were achieved in 7% of the patients, while partial eradication occurred in 17%. Significant adverse effects were noted in two patients (9%). Together with supportive measures, SBT/CPZ proved to be an effective and safe antibiotic for critically ill surgical patients.