Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever


Ozturk B., KUŞCU F., Tutuncu E., Sencan I., Gurbuz Y., Tuzun H.

JOURNAL OF CLINICAL VIROLOGY, vol.47, no.2, pp.115-119, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jcv.2009.10.015
  • Journal Name: JOURNAL OF CLINICAL VIROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.115-119
  • Keywords: Crimean-Congo hemorrhagic fever, Fatality, Hyaluronic acid, sVCAM-1, sICAM-1, VEGF-A, LEUKOCYTE ADHESION, ELEVATED LEVELS, ENDOTHELIAL-CELLS, PLASMA HYALURONAN, VIRUS-INFECTION, MOLECULES, SEVERITY, CHILDREN, VCAM-1

Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease. Pathogenesis of the disease has not been well described yet. A well-known pathogenic feature of CCHF virus is its capability to damage endothelium. Increased hyaluronic acid (HA) levels indicate liver sinusoidal endothelial damage. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor-A (VEGF-A) play a role in the inflammatory process, vascular damage and plasma leakage.