Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats


Anadol A. Z. , Bayram O., Dursun A., Ercan S.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.59, sa.4, ss.279-283, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Konu: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0952-3278(98)90142-9
  • Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Sayfa Sayıları: ss.279-283

Özet

In this study, the effects of BQ123 tan ETA receptor antagonist), bosentan (a nonselective ETA-ETB antagonist), and phosphoramidon tan endothelin converting enzyme inhibitor) were investigated on intestinal mucosal lesion formation and changes in tissue PGE(2) and LTC4 levels due to intestinal ischemia-reperfusion (I/R) injury in rats. Following 30 min of ischemia, the substances were given via the inferior caval vein, and 10 min later the intestine was subjected to reperfusion for 30 min. The intestinal specimens were evaluated both microscopically and the tissue PGE(2) and LTC4 levels were obtained for each group.