Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats

Anadol, AHMET; Bayram, O; Dursun, A; Ercan, S

doi:10.1016/s0952-3278(98)90142-9

Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats

Anadol A. Z., Bayram O., Dursun A., Ercan S.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.59, sa.4, ss.279-283, 1998 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 4
Basım Tarihi: 1998
Doi Numarası: 10.1016/s0952-3278(98)90142-9
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.279-283
Gazi Üniversitesi Adresli: Evet

Özet

In this study, the effects of BQ123 tan ETA receptor antagonist), bosentan (a nonselective ETA-ETB antagonist), and phosphoramidon tan endothelin converting enzyme inhibitor) were investigated on intestinal mucosal lesion formation and changes in tissue PGE(2) and LTC4 levels due to intestinal ischemia-reperfusion (I/R) injury in rats. Following 30 min of ischemia, the substances were given via the inferior caval vein, and 10 min later the intestine was subjected to reperfusion for 30 min. The intestinal specimens were evaluated both microscopically and the tissue PGE(2) and LTC4 levels were obtained for each group.