The Role of Adiponectin in The Immunopathogenesis of Multiple Sclerosis

Arli B., Irkec C.

MEDICAL JOURNAL OF BAKIRKOY, cilt.11, sa.3, ss.95-98, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5350/btdmjb201511301
  • Dergi Adı: MEDICAL JOURNAL OF BAKIRKOY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.95-98
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Adiponectin from adipocytokines plays role in neuro-inflammation, neuroimmunoendocrine system modulation and immune system regulation and has anti-inflammatory and protective effects. It functions by interacting pro-inflammatory cytokines, vasoactive peptides and complement proteins through peripheral and central mechanisms. The studies related to immunopathogenesis of Multiple Sclerosis (MS) progressing with neuroinflammation and neurodegeneration are focused on immune cells, cytokine, chemokines, membrane proteins, adhesion molecules and gene polymorphisms. We planned to determine the role of adipocyte related adiponectin in MS immunopathogenesis since the immunological functions of adipose tissue has drawn attention in the last years.