The Role of Adiponectin in The Immunopathogenesis of Multiple Sclerosis

Arli B., Irkec C.

MEDICAL JOURNAL OF BAKIRKOY, vol.11, no.3, pp.95-98, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.5350/btdmjb201511301
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.95-98
  • Gazi University Affiliated: Yes


Objective: Adiponectin from adipocytokines plays role in neuro-inflammation, neuroimmunoendocrine system modulation and immune system regulation and has anti-inflammatory and protective effects. It functions by interacting pro-inflammatory cytokines, vasoactive peptides and complement proteins through peripheral and central mechanisms. The studies related to immunopathogenesis of Multiple Sclerosis (MS) progressing with neuroinflammation and neurodegeneration are focused on immune cells, cytokine, chemokines, membrane proteins, adhesion molecules and gene polymorphisms. We planned to determine the role of adipocyte related adiponectin in MS immunopathogenesis since the immunological functions of adipose tissue has drawn attention in the last years.