Synthesis and biological studies of novel hydroxyacetophenone-tetrazole hybrids
ORGANIC COMMUNICATIONS, cilt.16, ss.75-86, 2023 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16
- Basım Tarihi: 2023
- Doi Numarası: 10.25135/acg.oc.148.2302.2696
- Dergi Adı: ORGANIC COMMUNICATIONS
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.75-86
- Gazi Üniversitesi Adresli: Evet
Özet
A series of novel hybrid compounds was synthesized where 2 '-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H-and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 mu g/ml. 4a and 5d were the most active antibacterial members.