Nitric oxide, lipid peroxides, and uric acid levels in pre-eclampsia and eclampsia


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Pasaoglu H., Bulduk G., Ogus E., Pasaoglu A., Onalan G.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol.202, no.2, pp.87-92, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 202 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1620/tjem.202.87
  • Journal Name: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.87-92
  • Keywords: pre-eclampsia, eclampsia, nitric oxide, lipid peroxidation, uric acid, OXIDATIVE STRESS, NORMAL-PREGNANCY, SERUM NITRATE, WOMEN, METABOLITES, PLASMA, ANTIBODIES, PRODUCTS
  • Gazi University Affiliated: Yes

Abstract

The aim was to study the role of nitric oxide (NO), lipid peroxides (LPX), and uric acid in pre-eclampsia and eclampsia. Plasma levels of NO metabolites (nitrite+nitrate), malonyldialdehyde (MDA), and uric acid and erythrocyte MDA levels were compared between. normal pregnant, pre-eclamptic, and eclamptic pregnant women in third trimester. Student's t-test was used for statistical evaluation. Plasma NO metabolites levels were higher in eclamptic group (35.7 +/- 16.5 mumol/liter, p<0.05) but not in pre-eclamptic group (22.1 +/- 10.8 mumol/liter) than control group (18.8 +/- 6.9 mumol/liter). Plasma MDA and uric acid concentrations were higher in preeclamptic (4.4 +/- 1.7 nmol/ml, p<0.05; 0.45 +/- 0.11 mmol/liter, p<0.05, respectively) and eclamptic (5.8 +/- 1.9 nmol/ml, p<0.05; 0.47 +/- 0.12 mmol/liter, p<0.05) groups compared with control group (3.0 +/- 1.3 nmol/ml; 0.35 +/- 0.06 mmol/liter). Erythrocytes MDA concentrations were higher only in eclamptic group (174.4 +/- 62 nmol/gHb, p<0.05) than control group (139.2 +/- 49.5 nmol/gHb). These results suggest that NO, LPX, and uric acid are important factors in the pathogenesis of pre-eclampsia and eclampsia, and that NO production and LPX are directly related to the severity of disease.