Changes in oxidative stress and cellular immunity serum markers in attention-deficit/hyperactivity disorder

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Ceylan M. F. , Sener S., Bayraktar A. C. , KAVUTÇU M.

PSYCHIATRY AND CLINICAL NEUROSCIENCES, vol.66, no.3, pp.220-226, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1440-1819.2012.02330.x
  • Page Numbers: pp.220-226


Aims: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder with an etiopathogeny not fully understood. According to the prevailing view, the main factors contributing to the disorder are prefrontal dopamine deficiency and central dopaminergic dysfunction, but the factors/mechanisms involved in the brain dysfunction and its consequences are not well known. We suggest that changes in oxidative metabolism and cellular immunity may be involved. In this study, we aimed to investigate whether there are associations between ADHD and changes in serum levels of nitric oxide synthase (NOS), xanthine oxidase (XO), glutathione S-transferase (GST) and paraoxonase-1 (PON-1) activities, which are important markers of oxidative stress, and adenosine deaminase (ADA) activity, marker of cellular immunity.