Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non-diabetic erectile dysfunction


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Tuncayengin A., Biri H., ONARAN M., Sen İ., Tuncayengin O., Polat F., ...Daha Fazla

INTERNATIONAL JOURNAL OF ANDROLOGY, cilt.26, sa.4, ss.250-254, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1046/j.1365-2605.2003.00427.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF ANDROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.250-254
  • Anahtar Kelimeler: diabetes mellitus, erectile dysfunction, glutathione, malondialdehyde, nitric oxide, SMOOTH-MUSCLE RELAXATION, GLYCATION END-PRODUCTS, LIPID-PEROXIDATION, PENILE ERECTION, DEPENDENT INHIBITION, OXIDE, LIVER, RATS, IMPOTENCE, PROTEIN
  • Gazi Üniversitesi Adresli: Evet

Özet

The aim of this study is to investigate the role of nitric oxide (NO) stabile end products, membrane lipid peroxidation and antioxidant defensive mechanism in diabetic erectile dysfunction (ED) and compare these parameters with non-diabetic ED groups. We examined the penile cavernosal tissues, obtained from 22 patients who had undergone surgery of penile prostheses implantation, for the nitrite, nitrate, malondialdehyde (MDA) and glutathione (GSH) levels. Eight patients were suffering from diabetic erectile dysfunction (ED) and 14 patients had non-diabetic ED. Nitrite and nitrate levels were lower; MDA and GSH levels were higher in the diabetic group. There were statistically significant differences between diabetic and non-diabetic groups amongst the nitrite (p < 0.001), nitrate (p < 0.01), MDA (p < 0.001) and GSH (p < 0.01) levels. Our data provide evidence that NO deficiency, possibly due to the membrane lipid peroxidation and defective antioxidant defensive mechanism, may contribute to the development of diabetic ED and thus is involved in the pathogenesis of ED in diabetic patients.