Is the Urinary Protein Excretion Pattern Compatible with Renal Morphological Findings in Renal Amyloidosis?


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Erdoan O., Demircin G., Buelbuel M., Memis L., Oener A.

RENAL FAILURE, vol.31, no.1, pp.13-17, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1080/08860220802546305
  • Title of Journal : RENAL FAILURE
  • Page Numbers: pp.13-17

Abstract

The aims of this study are to compare urinary protein excretion pattern with renal morphological findings and to find out whether urinary protein excretion pattern is a prognostic indicator of renal amyloidosis. Fifteen children with renal amyloidosis secondary to familial Mediterranean fever were included in the study. The patients were classified into three groups according to the degree of tubulointerstitial injury in renal biopsy (group 1, 25%; group 2, 25-50%; and group 3, 50%). In all patients, urinary protein electrophoresis were performed. Levels of urinary 2-microglobulin, retinol binding protein, and .N-acetyl-D glucosaminidase were measured as markers for tubular injury, and urinary excretions of protein and albumin and plasma albumin levels were measured as markers of glomerular injury. While urinary excretions of protein and albumin and plasma albumin levels were not different between groups, higher urinary 2-microglobulin and retinol binding protein values and lower creatinine clearance values were found in group 3 than in groups 1 and 2 (p 0.05). We concluded that analysis of urinary protein excretion pattern is a non-invasive and reliable method to detect the degree of tubulointerstitial injury as the most important prognostic factor in renal amyloidosis and may be used to determine the changes during the follow-up period of the patients.