Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation

Yanmaz V., DİŞLİ A., YAVUZ S., Ogutcu H., Dilek G.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.32, no.1, pp.78-89, 2019 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2019
  • Journal Indexes: Emerging Sources Citation Index, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.78-89
  • Keywords: Isoxazolidine, Nitrone, 1,3-Dipolar cycloaddition reaction, Antimicrobial activity, ANTIBACTERIAL, ANTIFUNGAL, INHIBITORS, ARYL, EFFICIENT, NITRONES, AGENTS, ROUTE


A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reactions of alpha-aryl-N-methyl nitrones with diethyl maleate. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.