EFFECT OF PREOPERATIVE I M ADMINISTRATION OF DICLOFENAC ON SUXAMETHONIUM-INDUCED MYALGIA


KAHRAMAN S., ERCAN S., AYPAR U., ERDEM K.

BRITISH JOURNAL OF ANAESTHESIA, vol.71, no.2, pp.238-241, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 2
  • Publication Date: 1993
  • Doi Number: 10.1093/bja/71.2.238
  • Title of Journal : BRITISH JOURNAL OF ANAESTHESIA
  • Page Numbers: pp.238-241
  • Keywords: ANALGESICS, DICLOFENAC, COMPLICATIONS, MYALGIA, NEUROMUSCULAR RELAXANTS, SUXAMETHONIUM, ASPIRIN-LIKE DRUGS, BETA-ENDORPHIN, PLASMA, PROSTAGLANDINS, PRETREATMENT, PREGNANCY, PARTURITION, DAMAGE, LABOR, PAIN

Abstract

We have studied the effects of preoperative administration of diclofenac on suxamethonium-induced myalgia, plasma met-enkephalin-like activity (E-LA), prostaglandin E2-like activity (PGE2-LA), leukotriene C4-like activity (LTC4-LA) and histamine-like activity (H-LA). Thirty-four ASA I patients undergoing elective ophthalmic surgery were allocated randomly to two groups to receive either saline placebo or diclofenac 75 mg i.m. 20 min before operation, in a double-blind design. Anaesthesia was induced with thiopentone 5-7 mg kg-1 followed by suxamethonium 1. 5 mg kg-1 and maintained with 67% nitrous oxide and halothane in oxygen. Plasma PGE2-LA, LTC4-LA, H-LA and E-LA were measured before premedication, 1 min after the administration of suxamethonium and 24 h after operation. Muscle fasciculations, intubation conditions and postoperative myalgia were graded numerically. Postoperative myalgia in the diclofenac group was significantly (P < 0.05) less (47.1%) than in the control gro up (76.5%). Post-suxamethonium and 24-h concentrations of plasma PGE2-LA and LTC4-LA were also significantly (P < 0.05) greater than baseline in the control group. Plasma H-LA was increased in both groups after suxamethonium and this increase was significant (P < 0.05) in the control group. We conclude that diclofenac reduces significantly the incidence and intensity of suxamethonium-induced myalgia.