Determination of possible genotoxic damage by comet assay in patients under treatment due to depression and anxiety disorders

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Atıf İçin Kopyala

Özden S., Yüzbaşıoğlu D., Özdamar G., Ünal F.

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.24, sa.2, ss.594-607, 2022 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 24 Sayı: 2
• Basım Tarihi: 2022
• Doi Numarası: 10.25092/baunfbed.1008498
• Dergi Adı: Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi
• Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.594-607
• Gazi Üniversitesi Adresli: Evet

Özet

Anxiety and depression, very common disorders today, are often seen together. The present study was designed to detect DNA damage in patients diagnosed and treated with depression and anxiety using the Comet test. Thirty-eight patients who received pharmacological therapy (selective serotonin reuptake inhibitors-SSRIs, selective norepinephrine reuptake inhibitors-SNRIs, and antipsychotics) for anxiety and depression and twenty-eight healthy volunteers were included in the study. The comet test was used to evaluate the DNA damage in peripheral blood lymphocytes. As a result, DNA damage in patients in all the treatment groups was higher than those in the control group. It was determined that factors such as age, gender, initial or recurrent diagnosis, SNRI or SSRI use, and fluoxetine use did not cause a statistically significant difference in DNA damage in patient groups. This study revealed that both depression and anxiety disease and the treatment of the disease may present a risk factor for DNA damage.