(2-Benzylidenehydrazino) benzoxazole derivatives, synthesis and antifungal activities


Ersan S., Tosun A., Bercin E., BAYTAŞ S., Uzunoglu S., Abbasoglu U.

Gazi Universitesi Eczacilik Fakultesi Dergisi, vol.12, no.2, pp.103-111, 1995 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 1995
  • Journal Name: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.103-111
  • Keywords: 2-hydrazinobenzoxazole, antifungal activity, arylaldehydehydrazone
  • Gazi University Affiliated: Yes

Abstract

Benzoxazole-2-thione as the starting material has been synthesized, and 2-methylthiobenzoxazole has been obtained therefrom. 2-Hydrazinobenzoxazole has been prepared from 2-methylthiobenzoxazole by heating with hydrazine hydrate under pressure in ethanol. Substituted arylhydrazones have been synthesized by the reaction of 2-hydrazinobenzoxazole with o- or p-substituted arylaldehydes, and antifungal activities of the synthesized compounds have been tested against yeast-like fungi such as Candida albicans, Candida stellatoidea, Candida parapsilosis, Candida pseudotropicalis.