The effects of topical granulocyte-macrophage colony-stimulating factor on dural healing in rats after induced cerebrospinal. fluid leakage


Kurt G., Boercek A. Ö. , Cemil B., Ucankus N. L. , Dogulu F., Baykaner M. K.

JOURNAL OF NEUROSURGERY-SPINE, vol.7, no.4, pp.419-422, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.3171/spi-07/10/419
  • Title of Journal : JOURNAL OF NEUROSURGERY-SPINE
  • Page Numbers: pp.419-422

Abstract

Object. Dural defects must be repaired to protect the central nervous system from contamination. Although there are various experimental and commercial substances available for this purpose, the ultimate method of watertight dural closure has yet to be discovered. In this study, the authors investigate the effects of topically applied recombinant mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) on dural healing in a rat model of dural injury and cerebrospinal fluid leakage.