Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis


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KEKİLLİ M., Tunc B., BEYAZIT Y., Kurt M., Onal I. K. , Ulker A., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.58, no.5, pp.1250-1255, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1007/s10620-012-2511-y
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1250-1255
  • Keywords: Ulcerative colitis, Primary sclerosing cholangitis, CD4+CD25+T cells, Pathophysiology, LIVER-TRANSPLANTATION, PATIENT, PROCTOCOLECTOMY, EXPANSION, CANCER
  • Gazi University Affiliated: No

Abstract

Immunopathogenetic features of primary sclerosing cholangitis (PSC) in ulcerative colitis (UC) still remains unclear. Peripheral blood CD4+CD25+ regulatory T cells have a key role in the induction and maintenance of peripheral self-tolerance and inhibit several organ-specific autoimmune diseases. Therefore, CD4+CD25+ T cells are believed to play an essential role in autoimmune diseases. The aim of the present study is to analyze the role of CD4+CD25+ T cells in the pathogenesis of UC-associated PSC.