Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis

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KEKİLLİ M., Tunc B., BEYAZIT Y., Kurt M., Onal I. K., Ulker A., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.58, sa.5, ss.1250-1255, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10620-012-2511-y
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1250-1255
  • Anahtar Kelimeler: Ulcerative colitis, Primary sclerosing cholangitis, CD4+CD25+T cells, Pathophysiology, LIVER-TRANSPLANTATION, PATIENT, PROCTOCOLECTOMY, EXPANSION, CANCER
  • Gazi Üniversitesi Adresli: Hayır

Özet

Immunopathogenetic features of primary sclerosing cholangitis (PSC) in ulcerative colitis (UC) still remains unclear. Peripheral blood CD4+CD25+ regulatory T cells have a key role in the induction and maintenance of peripheral self-tolerance and inhibit several organ-specific autoimmune diseases. Therefore, CD4+CD25+ T cells are believed to play an essential role in autoimmune diseases. The aim of the present study is to analyze the role of CD4+CD25+ T cells in the pathogenesis of UC-associated PSC.