Combination of DKK1 and AFP improves diagnostic accuracy of hepatocellular carcinoma compared with either marker alone


Erdal H., Utku O. G. , Karatay E., ÇELİK B. , Elbeg S., DOĞAN İ.

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.27, no.4, pp.375-381, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.5152/tjg.2016.15523
  • Title of Journal : TURKISH JOURNAL OF GASTROENTEROLOGY
  • Page Numbers: pp.375-381

Abstract

Background/Aims: The Wnt/beta-catenin pathway plays a prominent role in hepatocellular carcinoma (HCC). The Dickkopf (DKK) proteins (DKK1-4) are known Wnt antagonists; the overexpression of DKK1 has been demonstrated in HCC, and increased DKK3 methylation in the HCC tissue is associated with worse prognosis. Thus, the aim of our study was to demonstrate the diagnostic accuracy of serum DKK1 and DKK3 in HCC in comparison with that of serum alpha-fetoprotein (AFP).