Combination of DKK1 and AFP improves diagnostic accuracy of hepatocellular carcinoma compared with either marker alone

Erdal H., Utku O. G., Karatay E., ÇELİK B., Elbeg S., DOĞAN İ.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.27, sa.4, ss.375-381, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/tjg.2016.15523
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.375-381
  • Anahtar Kelimeler: Alpha-fetoprotein, diagnosis, Dickkopf proteins, hepatocellular carcinoma, biomarker, SERUM ALPHA-FETOPROTEIN, HEPATITIS-C, CIRRHOSIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/Aims: The Wnt/beta-catenin pathway plays a prominent role in hepatocellular carcinoma (HCC). The Dickkopf (DKK) proteins (DKK1-4) are known Wnt antagonists; the overexpression of DKK1 has been demonstrated in HCC, and increased DKK3 methylation in the HCC tissue is associated with worse prognosis. Thus, the aim of our study was to demonstrate the diagnostic accuracy of serum DKK1 and DKK3 in HCC in comparison with that of serum alpha-fetoprotein (AFP).