Akademik Veri Yönetim Sistemi
HEART & LUNG, cilt.71, ss.56-62, 2025 (SCI-Expanded)
Background: Myocardial perfusion single photon emission computed tomography (SPECT) and electrocardiogram (ECG) are crucial modalities in the evaluation of coronary artery disease(CAD) in clinical practice. Objective: To evaluate the relationship between ventricular repolarization parameters, index of cardiac electrophysiological balance (iCEB) from basal electrocardiograms (ECG), and reversible ischemia findings on SPECT. Methods: A total of 45 patients with reversible ischemia on 99m technetium-sestamibi (99mTc-MIBI) stress-rest myocardial perfusion SPECT and confirmed CAD by coronary angiography were included in the ischemia group. Forty-five patients with normal scans, matched by age and gender with the ischemia patient group, were included in the control group. The two-day 99mTc-MIBI SPECT protocol was performed with adenosinepharmacologic stress. The presence of ischemia and reversible ischemia size (RIS) were recorded in the ischemia group. The summed stress scores (SSS) were recorded for the ischemia and control groups. The QRS, QTd, cQTd, Tp-Te, Tp-Te/QT, Tp-Te/cQT, iCEB (QT/QRS), and iCEBc (cQT/QRS) were calculated. Correlations between myocardial perfusion SPECT and ECG parameters were evaluated using the Spearman test. Predictors of reversible ischemia were assessed using logistic regression analysis. Results: The ischemia group showed significantly higher values for QRS duration (p = 0.018), cQTmax (p = 0.006), QTd (p = 0.002), and cQTd (p = 0.003). Tp-Te (p = 0.004), Tp-Te/QT ratio (p = 0.003), and Tp-Te/cQT ratio (p = 0.002) were significantly lower in the ischemia group. The multivariate analysis showed that hyperlipidemia, QRS duration, cQTd, and Tp-Te/QTc ratio were found as independent predictors of ischemia. Conclusion: The Tp-Te/cQT ratio, QRS duration, and cQTd might be valuable predictors of reversible ischemia in SPECT, warranting further study.