Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots ofPerovskia atriplicifoliaBenth.

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Slusarczyk S., Senol Deniz F. S., Abel R., Pecio L., Perez-Sanchez H., Ceron-Carrasco J. P., ...Daha Fazla

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.21, sa.12, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/ijms21124475
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: tanshinones, cholinesterases, molecular docking, structure elucidation, IN-VITRO, CHOLINESTERASE-INHIBITORS, ABIETANE DITERPENOIDS, SALVIA-MILTIORRHIZA, CHARGES, MOUSE, TOOL
  • Gazi Üniversitesi Adresli: Evet

Özet

Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids fromPerovskia atriplicifoliaand other Lamiaceae species. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by the three new natural compounds-(1R,15R)-1-acetoxycryptotanshinone (1), (1R)-1-acetoxytanshinone IIA (2), and (15R)-1-oxoaegyptinone A (3)-as well as, new for this genus, isograndifoliol (4) were assessed. Three of these compounds exhibited profound inhibition of butyrylcholinesterase (BChE) and much weaker inhibition of acetylcholinesterase (AChE). All compounds (1-4) selectively inhibited BChE (IC50= 2.4, 7.9, 50.8, and 0.9 mu M, respectively), whereas only compounds3and4moderately inhibited AChE (IC(50)329.8 mu M and 342.9 mu M). Molecular docking and in silico toxicology prediction studies were also performed on the active compounds. Natural oxygenated norditerpenoids from the traditional Central Asian medicinal plantP. atriplicifoliaare selective BChE inhibitors. Their high potential makes them useful candidate molecules for further investigation as lead compounds in the development of a natural drug against dementia caused by neurodegenerative diseases.