Akademik Veri Yönetim Sistemi
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.20, sa.3, ss.363-369, 2011 (SCI-Expanded)
Solitary fibrous tumors are rarely seen slow-growing tumors of the pleura that immunohistochemical and ultrastructural methods show to be localized fibrous tumors. In 80% of the cases, they originate in the visceral pleura. They may also appear in other serosal membranes like the peritoneum or pericardium; or in non-serosal tissues like the paranasal sinuses, nose, mediastinum, liver, lung parenchyma or orbita. The study investigated 21 cases (10 males and 11 females) diagnosed with solitary fibrous tumors between January 1998 and January 2008. In the study group, the lesions in two patients were regarded as malignant with 5-8 mitoses in multiple locations; the tumors in the remaining nineteen patients had benign characteristics. In one patient a tumor with benign features underwent a malignant transformation 22 months after surgery, and the patient died 41 months after the first operation. The longest follow-up period was 112 months. Solitary fibrous tumors have malignant potential and therefore require long follow-up periods. The mitosis rate is a better indicator of the survival rate rather than tumor mass is. Shorter follow-up intervals are recommended for tumors radiologically detected in multiple locations and for those with higher mitosis rates, even if they are pathologically benign (Adv Clin Exp Med 2011, 20, 3, 363-369).