EGF Impact on Glycosaminoglycan Levels of the Brain

Balabanli B., Tiktik Z., Balaban T.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.28, no.2, pp.181-184, 2015 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2015
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.181-184
  • Gazi University Affiliated: Yes


Various growth factors such as epidermal growth factor (EGF) are effective proteins in wound healing. Glycosaminoglycans (GAG) can support the healing of wound by the growth factors as well as they are effective in recovery. Because of this reason, the changes occurring in GAG and protein levels synthesized from the hepatic tissue due to EGF applied systemically during physiologic wound healing process. 48 Wistar-Albino male rats were used in experiments. Rats to which dorsolateral excisional wound was made were divided into 2 equal groups: 1-The group left to spontaneous recovery, 2-Systemic EGF applied group. A daily dose of EGF (10 ng/mL) was given intraperitoneally (ip) to the animals in the application group. Rats were sacrificed under anesthesia in 1st, 5th, 7th and 14th days of the study. GAG and protein concentrations in brain tissues were measured spectrophotometrically. The results were compared by Mann Whitney U test. It was determined that the GAG level in brain was not effective in normal recovery process in peripheral injuries and systemically applied EGF increased GAG synthesis especially in the 7th day and it contributed to the healing by increasing the protein synthesis in the 7th day in which tissue repair is the highest.