Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones


Cakir B., Yildirim E., Ercanli T., Erol K., Sahin M.

FARMACO, vol.54, pp.842-845, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00110-x
  • Title of Journal : FARMACO
  • Page Numbers: pp.842-845

Abstract

Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others. (C) 1999 Elsevier Science S.A. All rights reserved.