Prefrontal Cortex Neurochemical Metabolite Levels in Major Depression and the Effects of Treatment: An (HMRS)-H-1 Study


Oguzhanoglu N. K. , Sozeri-Varma G., KARADAĞ R. F. , Tumkaya S., Efe M., Kiroglu Y.

TURK PSIKIYATRI DERGISI, vol.25, no.2, pp.75-83, 2014 (Journal Indexed in SSCI) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 2
  • Publication Date: 2014
  • Title of Journal : TURK PSIKIYATRI DERGISI
  • Page Numbers: pp.75-83
  • Keywords: Major depression, prefrontal cortex, magnetic resonance spectroscopy (HMRS), antidepressant, group psychotherapy, MAGNETIC-RESONANCE-SPECTROSCOPY, N-ACETYL-ASPARTATE, MATTER BIOCHEMICAL-ABNORMALITIES, COGNITIVE-BEHAVIORAL THERAPY, PROTON MR SPECTROSCOPY, UNIPOLAR DEPRESSION, DISORDER, BRAIN, NEUROANATOMY, METAANALYSIS

Abstract

Objective: Neuronal degeneration in the prefrontal cortex during depression results in altered production of neurochemical metabolites. The aim of the present study is to examine changes in neurochemical metabolites in the prefrontal cortex and evaluate the effects of psychodrama group therapy and pharmacotherapy on neurochemical metabolism in the first episode depression using (HMRS)-H-1 methodology.