Prefrontal Cortex Neurochemical Metabolite Levels in Major Depression and the Effects of Treatment: An (HMRS)-H-1 Study

Oguzhanoglu N. K., Sozeri-Varma G., KARADAĞ R. F., Tumkaya S., Efe M., Kiroglu Y.

TURK PSIKIYATRI DERGISI, cilt.25, sa.2, ss.75-83, 2014 (SSCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2014
  • Dergi Adı: TURK PSIKIYATRI DERGISI
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-83
  • Anahtar Kelimeler: Major depression, prefrontal cortex, magnetic resonance spectroscopy (HMRS), antidepressant, group psychotherapy, MAGNETIC-RESONANCE-SPECTROSCOPY, N-ACETYL-ASPARTATE, MATTER BIOCHEMICAL-ABNORMALITIES, COGNITIVE-BEHAVIORAL THERAPY, PROTON MR SPECTROSCOPY, UNIPOLAR DEPRESSION, DISORDER, BRAIN, NEUROANATOMY, METAANALYSIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Neuronal degeneration in the prefrontal cortex during depression results in altered production of neurochemical metabolites. The aim of the present study is to examine changes in neurochemical metabolites in the prefrontal cortex and evaluate the effects of psychodrama group therapy and pharmacotherapy on neurochemical metabolism in the first episode depression using (HMRS)-H-1 methodology.