European multicentre database of healthy controls for [I-123]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis


Varrone A., Dickson J. C. , Tossici-Bolt L., Sera T., Asenbaum S., Booij J., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.40, sa.2, ss.213-227, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00259-012-2276-8
  • Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Sayfa Sayıları: ss.213-227

Özet

Dopamine transporter (DAT) imaging with [I-123]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [I-123]FP-CIT SPECT scans in healthy controls.