European multicentre database of healthy controls for [I-123]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

Varrone A., Dickson J. C., Tossici-Bolt L., Sera T., Asenbaum S., Booij J., ...More

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol.40, no.2, pp.213-227, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1007/s00259-012-2276-8
  • Journal Name: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.213-227
  • Keywords: Dopamine transporter, Gender difference, Age effects, SPECT, Scatter correction, Database, PARKINSONS-DISEASE, DOPAMINE TRANSPORTERS, I-123-FP-CIT SPECT, BRAIN, PREVALENCE, NEUROTRANSMISSION, PROGRESSION, DIAGNOSIS, LEVODOPA, DECLINE
  • Gazi University Affiliated: Yes

Abstract

Dopamine transporter (DAT) imaging with [I-123]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [I-123]FP-CIT SPECT scans in healthy controls.