Drug-drug interactions in patients using tyrosine kinase inhibitors: A multicenter retrospective study

Ergun Y., Ozdemir N. Y. , Toptas S., Kurtipek A., Eren T., Yazic O., ...More

JOURNAL OF BUON, vol.24, no.4, pp.1719-1726, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2019
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1719-1726
  • Keywords: tyrosine kinase inhibitors, drug-drug interactions, antibiotics, proton pump inhibitors, cancer, CANCER-PATIENTS, P-GP, ABSORPTION, PHARMACOKINETICS, KETOCONAZOLE, PREVALENCE, MEDICATION, METABOLISM, PAZOPANIB, AGENTS
  • Gazi University Affiliated: Yes


Purpose: Tyrosine kinase inhibitors (TKIs) are frequently used drugs in oncology practice. Although oral administration is an advantage, long-term use increases potential drug-drug interaction risk. The purpose of this study was to assess the prevalence of potential TKI-drug interaction (PTDI) in patients who used TKIs and increase awareness of this subject.