Synthesis and analgesic and antiinflammatory activity of ethyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives

DÜNDAR Y. , Goekce M., Kuepeli E., Sahin M. F.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.57, sa.12, ss.777-781, 2007 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Konu: 12
  • Basım Tarihi: 2007
  • Sayfa Sayıları: ss.777-781


A number of 6-substituted-3(2H) -pyridazinones and the corresponding methyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives carrying the arylpiperazinyl structure present in potent antinociceptive agents reported in the literature were synthesized. As part of a programme a series of diverse arylpiperazine derivatives of ethyl (6-substituted-3(2H) -pyridazinone-2-yl) acetate were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively.