Synthesis and analgesic and antiinflammatory activity of ethyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.57, sa.12, ss.777-781, 2007 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 12
- Basım Tarihi: 2007
- Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.777-781
- Gazi Üniversitesi Adresli: Evet
Özet
A number of 6-substituted-3(2H) -pyridazinones and the corresponding methyl (6-substituted-3(2H)-pyridazinone-2-yl)acetate derivatives carrying the arylpiperazinyl structure present in potent antinociceptive agents reported in the literature were synthesized. As part of a programme a series of diverse arylpiperazine derivatives of ethyl (6-substituted-3(2H) -pyridazinone-2-yl) acetate were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively.