Fatal anaplastic lymphoma kinase positive anaplastic large cell lymphoma presenting with cutaneous lesions: A case report

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Erduran F. B., ADIŞEN E., AKYÜREK N., Gurer M. A.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.51, sa.2, ss.52-55, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/turkderm.76148
  • Dergi Adı: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.52-55
  • Anahtar Kelimeler: Anaplastic, large cell lymphoma, CD30, anaplastic lymphoma kinase, primary cutaneous, LYMPHOPROLIFERATIVE DISORDERS, ALK
  • Gazi Üniversitesi Adresli: Evet

Özet

Anaplastic large-cell lymphoma (ALCL) is a CD30-positive non-Hodgkin lymphoma of T-cell origin. It comprises approximately 3% of all nonHodgkin lymphomas. The skin may be the primary involvement site (primary cutaneous) or systemic ALCL may affect the skin as cutaneous metastasis. In systemic ALCL, 80-85% of cases exhibit anaplastic lymphoma kinase-1 (ALK). However, primary cutaneous ALCL is typically ALK-negative. The most important prognostic marker in systemic ALCL is the expression of ALK. Positive ALK is associated with a favourable prognosis in systemic ALCL. Here, we report a case of ALK-positive ALCL with a very aggressive clinical course. Our case was evaluated for brown-violaceous nodules appearing on the trunk, groin and arm for about 3-4 weeks. In a few days after the diagnosis of ALCL, the patient died because of sepsis which was thought to be associated with ALCL.