Fatal anaplastic lymphoma kinase positive anaplastic large cell lymphoma presenting with cutaneous lesions: A case report
TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.51, sa.2, ss.52-55, 2017 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.4274/turkderm.76148
- Dergi Adı: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.52-55
- Anahtar Kelimeler: Anaplastic, large cell lymphoma, CD30, anaplastic lymphoma kinase, primary cutaneous, LYMPHOPROLIFERATIVE DISORDERS, ALK
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Anaplastic large-cell lymphoma (ALCL) is a CD30-positive non-Hodgkin lymphoma of T-cell origin. It comprises approximately 3% of all nonHodgkin lymphomas. The skin may be the primary involvement site (primary cutaneous) or systemic ALCL may affect the skin as cutaneous metastasis. In systemic ALCL, 80-85% of cases exhibit anaplastic lymphoma kinase-1 (ALK). However, primary cutaneous ALCL is typically ALK-negative. The most important prognostic marker in systemic ALCL is the expression of ALK. Positive ALK is associated with a favourable prognosis in systemic ALCL. Here, we report a case of ALK-positive ALCL with a very aggressive clinical course. Our case was evaluated for brown-violaceous nodules appearing on the trunk, groin and arm for about 3-4 weeks. In a few days after the diagnosis of ALCL, the patient died because of sepsis which was thought to be associated with ALCL.