The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease

Acar Cinleti B., Yardimci N., Ayturk Z., Ilhan A., Kaya G., Acar M., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1098-1105, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1407-19
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1098-1105
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid beta-peptide, which is derived from beta-amyloid precursor protein through degradation by beta-secretase and.-secretase complexes. One of the major components of gamma-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the.-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population.