Antineutrophil cytoplasmic antibody positivity and clinical implications in COVID-19

Güven S. C., Apaydln H., Özdemir B., Armaǧan B., Ateş I., Erden A., ...Daha Fazla

Future Virology, cilt.17, sa.4, ss.239-245, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3233/epl-210113
  • Dergi Adı: Future Virology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.239-245
  • Anahtar Kelimeler: ANCA, antineutrophil cytoplasmic antibody, COVID-19, mortality, outcome
  • Gazi Üniversitesi Adresli: Hayır

Özet

© 2022 Future Medicine Ltd.Aim: To investigate clinical implications of antineutrophil cytoplasmic antibody (ANCA) positivity detected in COVID-19 patients during follow up. Materials & methods: A retrospective survey in a hospital database was carried out to detect COVID-19 patients in which ANCAs had been tested. Clinical, laboratory and imaging data were collected from this hospital database and compared between ANCA-negative and-positive patients. Results: ANCAs were tested in 87 COVID-19 patients. Eight had positivity in at least one ANCA test. COVID-19 symptoms on admission and rate of pulmonary involvement were similar. Acute phase reactant levels were higher in ANCA-positive patients. Rate of mortality was higher in the ANCA-positive group without statistical significance. Conclusion: ANCA positivity detected during COVID-19 in patients without a prior diagnosis of any rheumatic condition may be related with worse outcomes.