Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis
Cell Biochemistry and Function, cilt.23, sa.4, ss.285-289, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1002/cbf.1155
- Dergi Adı: Cell Biochemistry and Function
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.285-289
- Anahtar Kelimeler: NA+K+ ATPase activity, Rheumatoid arthritis, Soluble E-selectin
- Gazi Üniversitesi Adresli: Evet
Özet
We conducted this study to assess serum soluble E-selectin (sE-selectin) levels and erythrocyte membrane Na+K+ ATPase activity in patients with rheumatoid arthritis (RA) and correlate the levels with disease activity. Levels of sE-selectin were measured in the serum of 20 patients with RA and 20 control subjects by an enzyme-linked immunosorbant assay. Na +K+ ATPase activity was determined by a colorimetric method in RA patients and healthy controls. There were no statistically significant differences between the two groups with respect to demographic data such as age and sex (p > 0.05). The serum levels of sE-selectin, ESR and C-reactive protein (CRP) in RA patients were significantly higher than in healthy controls (p < 0.001). Erythrocyte membrane Na+K + ATPase activity was significantly lower in the RA group than in the control group (p < 0.001). Correlation analysis revealed significant positive correlations between soluble E-selectin and ESR (r = 0.457; p < 0.05) and CRP (r = 0.682; p < 0.01) levels. There were statistically significant negative correlations between erythrocyte membrane Na +K+ ATPase activity and ESR (r = -0.450; p < 0.05) and CRP (r = -0.446; p < 0.05) levels. Additionally, a significant negative correlations between sE-selectin and Na+K+ ATPase activity was observed (r = -0.80; p < 0.001). These results show that decreases in erythrocyte membrane Na+K+ ATPase activity and increases in sE-selectin are observed in RA, and that increased levels of sE-selectin may also reflect disease status or activity. Copyright © 2004 John Wiley & Sons, Ltd.