Akademik Veri Yönetim Sistemi
Global Migraine & Pain Summit, 6th MENA Meeting & 4rd Turkish African Meeting Of Headache And Pain Management 2022, Antalya, Türkiye, 2 - 05 Kasım 2022, ss.34
Background: Systemic immune-inflammation index (SII) is a novel marker for chronic inflammation. Studies have shown an association between SII and many inflammatory diseases. The neutrophil-tolymphocyte ratio (NLR) is a well-defined peripheral blood marker of systemic inflammation. Neurogenic inflammation is the main component of migraine pathophysiology and systemic inflammation is considered to have an impact on neurogenic inflammation regarding many neurological disorders. Aim: The aim of this study is to evaluate systemic inflammatory status in different groups of migraine in which neurogenic inflammation plays a central role. Methods: 20 chronic migraine and 20 episodic migraine patients were included in the study. Inflammatory parameters derived from routine hemogram studies were recorded and SII and NLR were calculated. The values were compared between two migraine subgroups. p < 0.05 was considered statistically significant. Results: The mean SII value of the chronic migraine patients (mean 552.5x10 3 ± 186.0x10 3 ) was significanly higher (p = 0.001) compared to the mean SII value of the episodic migraine patients (383.9x103 ± 101.6x10 3 ). The mean NLR value of the chronic migraine patients (1.83 ± 0.44) was also significantly higher (p = 0.041) compared to the mean NLR value of the episodic migraine patients (1.57 ± 0.30). Conclusion: Chronic migraine patients were found to have higher SII and NLR values than episodic migraine patients. These results indicates that systemic inflammation has a pivotal role not only for migraine pathophysiology but also chronification of this headache disorder.