Solid-phase chemoenzymatic synthesis of C-sialosides
JOURNAL OF ORGANIC CHEMISTRY, cilt.69, sa.20, ss.6900-6903, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 20
- Basım Tarihi: 2004
- Doi Numarası: 10.1021/jo0491298
- Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.6900-6903
- Gazi Üniversitesi Adresli: Hayır
Özet
The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.