Solid-phase chemoenzymatic synthesis of C-sialosides


BAYTAŞ S. , Wang Q., Karst N., Dordick J., Linhardt R.

JOURNAL OF ORGANIC CHEMISTRY, cilt.69, sa.20, ss.6900-6903, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Konu: 20
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1021/jo0491298
  • Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.6900-6903

Özet

The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.