Solid-phase chemoenzymatic synthesis of C-sialosides


BAYTAŞ S. , Wang Q., Karst N., Dordick J., Linhardt R.

JOURNAL OF ORGANIC CHEMISTRY, vol.69, no.20, pp.6900-6903, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 20
  • Publication Date: 2004
  • Doi Number: 10.1021/jo0491298
  • Title of Journal : JOURNAL OF ORGANIC CHEMISTRY
  • Page Numbers: pp.6900-6903

Abstract

The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.