A novel ROCK inhibitor: off-target effects of metformin

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ÖZDEMİR A., ARK M.

TURKISH JOURNAL OF BIOLOGY, vol.45, no.1, pp.35-45, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.3906/biy-2004-12
  • Journal Name: TURKISH JOURNAL OF BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.35-45
  • Keywords: Connectivity MAP, Rho kinase, metformin, off-target effect, oral antidiabetics, RHO-ASSOCIATED KINASE, DRUG-TARGET, CANCER, CYTOSKELETON, REGULATOR
  • Gazi University Affiliated: Yes

Abstract

In drug discovery, most small molecules cannot cross many stages, only a few can become drug candidates. Once the drug molecule is approved and marketed, nontarget effects that are not easily distinguishable from the actual target of the drugs might be evaluated. This situation restricts the treatment. Thus, the discovery of new drugs is a very long and expensive process. In recent years, without developing new drugs, the approach of using different and new target molecules in new indications apart from the indications of licensed drug molecules has gained importance.