Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives

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Aytemir M., Özçelik B.

MEDICINAL CHEMISTRY RESEARCH, cilt.20, sa.4, ss.443-452, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00044-010-9338-x
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.443-452
  • Anahtar Kelimeler: Chlorokojic acid, Kojic acid, Mannich bases, Antimicrobial, Antiviral, KOJIC ACID, ANTICONVULSANT
  • Gazi Üniversitesi Adresli: Evet

Özet

A novel series of 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one derivatives were synthesized and tested for their antibacterial, antifungal and antiviral in vitro properties. In the view of activity results, compounds 8-11 (MIC: 8 mu g/ml) were more remarkably active against Staphylococcus aureus and Enterococcus faecalis. Compounds 1-7 were highly active against Candida albicans and C. parapsilosis with MIC value of 8 mu g/ml. Compound 9 bearing 3-chlorophenyl moiety was determined to be the most active compound against RNA virus PI-3.